MLKL signaling regulates macrophage polarization in acute pancreatitis through CXCL10
Selected Publications
Integrated Machine Learning and Bioinformatic Analyses Constructed a Novel Stemness-Related Classifier to Predict Prognosis and Immunotherapy Responses for Hepatocellular Carcinoma Patients
Interplay of four types of RNA modification writers revealed distinct tumor microenvironment and biological characteristics in pancreatic cancer
Murine Chronic Pancreatitis Model Induced by Partial Ligation of the Pancreatic Duct Encapsulates the Profile of Macrophage in Human Chronic Pancreatitis
Development and Verification of the Hypoxia- and Immune-Associated Prognostic Signature for Pancreatic Ductal Adenocarcinoma
All Publications
Prognostic Significance and Immune Landscape of Migrasome-Related Genes in Pancreatic Cancer
Ben Liu, Shuang Li, Wenzhe Gao, Hongwei Zhu, Pin Lyu, Xiao Yu*, Yuting Xiao*
Comprehensive analysis and therapeutic implications of prognostic value of circadian rhythm genes in hepatocellular carcinoma
Jichun Sun, Jiaxing Hou, Hongbo Xu, Zhiqiang Li, Zhen Deng, Zhi Yang, Wuqing Cao, Junning Hou, Xiaoxin Jin*
IL-18 promotes pancreatic fibrosis via release of IL-4 from pancreatic stellate cells and induces macrophage M2 polarization
Guangping Tu, Cheng Peng, Shuangxi Xie, Shixu Zheng, Haibo Jiang, Lang Chen, Xiao Yu, Zhiqiang Li*
Identification of the key gene for hepatocellular carcinoma based on bioinformatics and machine learning and experimental verification
Jin Lu†, Junjie Ma†, Can Yu, Shaoyang Lu, Xueying Zhao, Lei Zhang*
Integration of Immune Cell Signatures and Diagnostic Gene Markers in Pancreatitis: A Comprehensive Study on Therapeutic Targets and Predictive Diagnosis
Qianyu Xie, Birong Liu, Xiao Yu, Xiang Wei, Qiangsheng Xiao*
TH17 cells regulate chemokine expression in epithelial cells through C/EBPβ and dictate host sensitivity to colitis and cancer immunity
Changsheng Xing†, Tianhao Duan†, Linfeng Li, Lang Chen, Pengfei Zhang, Yang Du, Siyao Liu, Nihal Annaparthi, Shuo Wang, Chen Qian, Helen Y Wang, Rongfu Wang*
Development of a Hepatocyte-Specific Temporal Genetic Mouse Model Using Albumin Promoter-Driven FlpER2 Expression
Bin Wang, Jiale Wang, Yang Liu, Gordon He, Yasmin Jahan-Mihan, Yuxi Wang, Jie Hu, Audrey Li, Faheem Muhammad, Yan Bi, Baoan Ji
Temporal trends in cross-country inequalities of early-onset pancreatic cancer: a comprehensive analysis for the global burden of disease study 2021
Luohong Li†, Jiahao Li†, An Yan, Wei Xiang, Wenzhe Gao*, Hongwei Zhu*
A novel mouse model of diverse tumors derived from epithelial cells
Bin Wang, Lingxiang Wang, Yang Liu, Yasmin Jahan-Mihan, Gordon He, Yuxi Wang, Jie Hu, Jiale Wang, Yan Bi, Baoan Ji*
Investigating SNHG3 as a potential therapeutic approach for HCC stem cells
Dingmao Wang, Xiao Yu*, Yijun Yang*
Early onset pancreatic cancer: A review
Dong Luo, Yixiong Li, Xiao Yu, Liandong Ji*, Xuejun Gong*
A retrospective comparative study on the treatment of non-metastatic pancreatic cancer using high-intensity focused ultrasound versus radical surgery
Li Yu, Yunfei Liu, Zhiqiang Li, Yanyan Huang, Guangping Tu, Qiuling Shi*, Lang Chen*, Xiao Yu*
T-bet Regulates Ion Channels and Transporters and Induces Apoptosis in Intestinal Epithelial Cells
Lang Chen, Hongwei Yi, Qingtian Li, Tianhao Duan, Xin Liu, Linfeng Li, Helen Y Wang, Changsheng Xing, Rongfu Wang*
LncRNA HOXA‑AS2 is a prognostic and clinicopathological predictor in patients with cancer: A meta‑analysis
Tijun Xiao, An Yan, Lifang Tan, Hongwei Zhu, Wenzhe Gao*
IGF2BP2-related modification patterns in pancreatic cancer: A machine learning-driven approach towards personalized treatment
Dongjie Chen†, Longjun Zang†, Yanling Zhou, Yongchao Yang, Xianlin Zhang, Zheng Li, Yufeng Shu, Wenzhe Gao*, Hongwei Zhu*, Xiao Yu*
Albumin promoter-driven FlpO expression induces efficient genetic recombination in mouse liver
Xiaohui Zhu, Yan Yang, Dongfeng Feng, Oliver Wang, Jiaxiang Chen, Jiale Wang, Bin Wang, Yang Liu, Brandy H Edenfield, Ashley N Haddock, Ying Wang, Tushar Patel, Yan Bi, Baoan Ji*
PTEN deficiency induces an extrahepatic cholangitis-cholangiocarcinoma continuum via aurora kinase A in mice
Yan Yang†, Jiale Wang†, Jianhua Wan†, Qianqian Cheng, Zenong Cheng, Xueli Zhou, Oliver Wang, Kelvin Shi, Lingxiang Wang, Bin Wang, Xiaohui Zhu, Jiaxiang Chen, Dongfeng Feng, Yang Liu, Yasmin Jahan-Mihan, Ashley N Haddock, Brandy H Edenfield, Guang Peng, Jessica D Hohenstein, Chantal E McCabe, Daniel R O'Brien, Chen Wang, Sumera I Ilyas, Liuyan Jiang, Michael S Torbenson, Huamin Wang, Raouf E Nakhleh, Xuemei Shi, Ying Wang, Yan Bi, Gregory J Gores, Tushar Patel, Baoan Ji*
A simple and effective genotyping workflow for rapid detection of CRISPR genome editing
Lingxiang Wang, Jiale Wang, Dongfeng Feng, Bin Wang, Yasmin Jahan-Mihan, Ying Wang, Yan Bi, DoYoung Lim, Baoan Ji*
Activation of cGAS-STING signaling pathway promotes liver fibrosis and hepatic sinusoidal microthrombosis
Shaobin Luo, Rongkun Luo, Huanyuan Lu, Rui Zhang, Gang Deng, Hongwu Luo, Xiao Yu, Changfa Wang, Hui Zhang, Yuping Zhang, Wei Huang, Jichun Sun, Yinghong Liu, Feizhou Huang, Zhao Lei*
A mouse model for high-efficient Flp-recombinase-mediated genetic manipulation in the pancreas
Xiaohui Zhu, Jiaxiang Chen, Bin Wang, Lingxiang Wang, Jiale Wang, Dongfeng Feng, Yan Yang, Oliver Wang, Ashley N Haddock, Ying Wang, Baoan Ji, Yan Bi*
Upregulation of the ERRγ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis
Dipanjan Chanda†, Themis Thoudam†, Ibotombi Singh Sinam, Chae Won Lim, Myeongjin Kim, Jiale Wang, Kyeong Min Lee, Jing Ma, Romil Saxena, Jinhyuk Choi, Chang Joo Oh, Hoyul Lee, Yong Hyun Jeon, Sung Jin Cho, Hoe-Yune Jung, Keun-Gyu Park, Hueng-Sik Choi, Jae Myoung Suh, Johan Auwerx, Baoan Ji, Suthat Liangpunsakul, Jae-Han Jeon*, In-Kyu Lee*
Primary breast angiosarcoma: A case report
Yu He, Liyuan Qian, Lang Chen, Yang Liu, Yanguang Wen*, Peiguo Cao*
A Fluorescent Biosensor for Streptavidin Detection Based on Double-Hairpin DNA-Templated Copper Nanoparticles
Qiangsheng Xiao, Mingjian Chen, Wanpin Nie, Fengjiao Xie, Xiao Yu*, Changbei Ma*
MLKL signaling regulates macrophage polarization in acute pancreatitis through CXCL10
Cheng Peng, Guangping Tu, Jiale Wang, Yilin Wang, Peng Wu, Li Yu, Zhiqiang Li*, Xiao Yu*
The Prognostic Value of a lncRNA Risk Model Consists of 9 m6A Regulator-Related lncRNAs in Hepatocellular Carcinoma (HCC)
Zhen Deng†, Jiaxing Hou†, Hongbo Xu, Zhao Lei, Zhiqiang Li, Hongwei Zhu, Xiao Yu, Zhi Yang, Xiaoxin Jin, Jichun Sun*
DSCR9/miR-21-5p axis inhibits pancreatic cancer proliferation and resistance to gemcitabine via BTG2 signaling
Hui Huang, Xia Li, Xianlin Zhang, Zhiqiang Li, Duo Han, Wenzhe Gao, Ling Liu, Cheng Peng, Hongwei Zhu*, Xiao Yu*
Interplay of four types of RNA modification writers revealed distinct tumor microenvironment and biological characteristics in pancreatic cancer
Wenzhe Gao†, Dongjie Chen†, Jixing Liu†, Longjun Zang, Tijun Xiao, Xianlin Zhang, Zheng Li, Hongwei Zhu*, Xiao Yu*
Identification of biomarkers for hepatocellular carcinoma based on single cell sequencing and machine learning algorithms
Weimin Li†, Jixing Liu†, Wenjuan Zhu, Xiaoxin Jin, Zhi Yang, Wenzhe Gao*, Jichun Sun*, Hongwei Zhu*
Machine learning models identify ferroptosis-related genes as potential diagnostic biomarkers for Alzheimer's disease
Yanyao Deng†, Yanjin Feng†, Zhicheng Lv, Jinli He, Xun Chen, Chen Wang, Mingyang Yuan, Ting Xu, Wenzhe Gao, Dongjie Chen, Hongwei Zhu, Deren Hou*
Sema3d Restrained Hepatocellular Carcinoma Progression Through Inactivating Pi3k/Akt Signaling via Interaction With FLNA
Yiming Li, Cong Xu, Bo Sun, Fangjing Zhong, Momo Cao, Lianyue Yang*
Clinical Analysis of C-Shaped Embedded Pancreaticojejunostomy in Pancreaticoduodenectomy
Hui Huang, Jichun Sun, Zhiqiang Li, Longjun Zang, Hongwei Zhu, Xianlin Zhang, Xiao Yu*
The emerging role of NR2F1-AS1 in the tumorigenesis and progression of human cancer
Dong Luo, Yunfei Liu, Shuai Yuan, Xianyun Bi, Yongchao Yang, Hongwei Zhu, Zhiqiang Li*, LianDong Ji*, Xiao Yu*
Piezo1 promoted hepatocellular carcinoma progression and EMT through activating TGF-β signaling by recruiting Rab5c
Yiming Li, Cong Xu, Bo Sun, Fangjing Zhong, Momo Cao, Lianyue Yang*
Identification of EMT-Related lncRNAs as Potential Prognostic Biomarkers and Therapeutic Targets for Pancreatic Adenocarcinoma
Yanyao Deng, Hai Hu, Le Xiao, Ting Cai, Wenzhe Gao, Hongwei Zhu, Shuai Wang*, Jixing Liu*
Murine Chronic Pancreatitis Model Induced by Partial Ligation of the Pancreatic Duct Encapsulates the Profile of Macrophage in Human Chronic Pancreatitis
Cheng Peng†, Guangping Tu†, Li Yu, Peng Wu, Xianlin Zhang, Zheng Li, Zhiqiang Li*, Xiao Yu*
The NF-κB/miR-488/ERBB2 axis modulates pancreatic cancer cell malignancy and tumor growth through cell cycle signaling
Duo Han, Shaihong Zhu, Xia Li, Zhiqiang Li, Hui Huang, Wenzhe Gao, Yunfei Liu, Hongwei Zhu*, Xiao Yu*
Wild-Type Human PRSS2 and PRSS1R122H Cooperatively Initiate Spontaneous Hereditary Pancreatitis in Transgenic Mice
Jiale Wang, Jianhua Wan, Lingxiang Wang, Stephen J Pandol, Yan Bi*, Baoan Ji*
Impact of the tumor immune microenvironment on the outcome of pancreatic cancer: a retrospective study based on clinical pathological analysis
Hui Huang, Jichun Sun, Zhiqiang Li, Xianlin Zhang, Zheng Li, Hongwei Zhu*, Xiao Yu*
Risk factors and prognostic index model for pancreatic cancer
Hui Huang, Jichun Sun, Zheming Jiang, Xianlin Zhang, Zheng Li, Hongwei Zhu*, Xiao Yu*
Ferroptosis-Related IncRNAs Are Prognostic Biomarker of Overall Survival in Pancreatic Cancer Patients
Dongjie Chen†, Wenzhe Gao†, Longjun Zang, Xianlin Zhang, Zheng Li, Hongwei Zhu*, Xiao Yu*
Ptf1a Promoter-Driven Cre Expression During Spermatogenesis Causes Germline Recombination
Jiale Wang, Oliver Wang, Yan Bi, Ying Wang, Howard Crawford, Baoan Ji*
LncRNA AC099850.3 promotes hepatocellular carcinoma proliferation and invasion through PRR11/PI3K/AKT axis and is associated with patients prognosis
Fangjing Zhong, Sheng Liu, Donghai Hu, Liwen Chen*
The lncRNA CASC2 Modulates Hepatocellular Carcinoma Cell Sensitivity and Resistance to TRAIL Through Apoptotic and Non-Apoptotic Signaling
Jichun Sun†, Hongbo Xu†, Zhao Lei, Zhiqiang Li, Hongwei Zhu, Zhen Deng, Xiao Yu, Xiaoxin Jin*, Zhi Yang*
Integrated Machine Learning and Bioinformatic Analyses Constructed a Novel Stemness-Related Classifier to Predict Prognosis and Immunotherapy Responses for Hepatocellular Carcinoma Patients
Dongjie Chen†, Jixing Liu†, Longjun Zang, Tijun Xiao, Xianlin Zhang, Zheng Li, Hongwei Zhu*, Wenzhe Gao*, Xiao Yu*
Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis
Can Yu†, Zhao Lei†, Xia Li, Lihua Huang, Zhiqiang Li, Hongwei Zhu, Duo Han, Hui Huang, Xiao Yu*
Wogonoside inhibits TNF receptor-associated factor 6 (TRAF6) mediated-tumor microenvironment and prognosis of pancreatic cancer
Hui Huang, Xia Li, Li Yu, Ling Liu, Hongwei Zhu, Wei Cao, Zhongling Sun, Xiao Yu*
Development and Verification of the Hypoxia- and Immune-Associated Prognostic Signature for Pancreatic Ductal Adenocarcinoma
Dongjie Chen†, Hui Huang†, Longjun Zang, Wenzhe Gao*, Hongwei Zhu*, Xiao Yu*
GNA14's interaction with RACK1 inhibits hepatocellular carcinoma progression through reducing MAPK/JNK and PI3K/AKT signaling pathway
Cong Xu, Yiming Li, Bo Sun, Fangjing Zhong, Lianyue Yang*
NR2F1-AS1 Promotes Pancreatic Ductal Adenocarcinoma Progression Through Competing Endogenous RNA Regulatory Network Constructed by Sponging miRNA-146a-5p/miRNA-877-5p
Dong Luo, Yunfei Liu, Zhiqiang Li, Hongwei Zhu*, Xiao Yu*
Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation
Bo Sun, Fangjing Zhong, Cong Xu, Yiming Li, Yanrong Zhao, Momo Cao, Lianyue Yang*
ELTD1 Promotes Gastric Cancer Cell Proliferation, Invasion and Epithelial-Mesenchymal Transition Through MAPK/ERK Signaling by Regulating CSK
Bo Sun, Fangjing Zhong
Pancreas-specific CHRM3 activation causes pancreatitis in mice
Jianhua Wan†, Jiale Wang†, Larry E Wagner 2nd, Oliver H Wang, Fu Gui, Jiaxiang Chen, Xiaohui Zhu, Ashley N Haddock, Brandy H Edenfield, Brian Haight, Debabrata Mukhopadhyay, Ying Wang, David I Yule, Yan Bi, Baoan Ji*
ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/β-Catenin Signaling
Cong Xu, Yiming Li, Bo Sun, Fangjing Zhong, Lianyue Yang*
Microbiota regulate innate immune signaling and protective immunity against cancer
Changsheng Xing, Mingjun Wang, Adebusola A Ajibade, Peng Tan, Chuntang Fu, Lang Chen, Motao Zhu, Zhaozhe Hao, Junjun Chu, Xiao Yu, Bingnan Yin, Jiahui Zhu, Wanjou Shen, Tianhao Duan, Helen Y Wang, Rongfu Wang*
EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics
Fangjing Zhong, Yiming Li, Cong Xu, Bo Sun, Jilong Wang, Lianyue Yang*
STMN2 mediates nuclear translocation of Smad2/3 and enhances TGFβ signaling by destabilizing microtubules to promote epithelial-mesenchymal transition in hepatocellular carcinoma
Fangjing Zhong, Bo Sun, Momo Cao, Cong Xu, Yiming Li, Lianyue Yang*
S100A14 promotes progression and gemcitabine resistance in pancreatic cancer
Hongwei Zhu†, Wenzhe Gao†, Xia Li, Li Yu, Dong Luo, Yunfei Liu, Xiao Yu*
PVT1 Knockdown Inhibits Autophagy and Improves Gemcitabine Sensitivity by Regulating the MiR-143/HIF-1α/VMP1 Axis in Pancreatic Cancer
Yunfei Liu, Dong Luo, Xia Li, Zhiqiang Li, Xiao Yu*, Hongwei Zhu*
Expressional and Prognostic Value of S100A16 in Pancreatic Cancer Via Integrated Bioinformatics Analyses
Gangping Tu†, Wenzhe Gao†, Ying Li, Yating Dian, Bingyang Xue, Li Niu, Xiao Yu*, Hongwei Zhu*
The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis
Cheng Peng, Zhiqiang Li*, Xiao Yu*
Meta-analysis of the Diagnostic Performance of Circulating MicroRNAs for Pancreatic Cancer
Cheng Peng, Jiale Wang, Wenzhe Gao, Lihua Huang, Yunfei Liu, Xia Li, Zhiqiang Li*, Xiao Yu*
Circ_0005198 enhances temozolomide resistance of glioma cells through miR-198/TRIM14 axis
Yanyao Deng†, Hongwei Zhu†, Le Xiao, Chao Liu, Xiangrui Meng*
Identification and Development of Long Non-coding RNA Associated Regulatory Network in Pancreatic Adenocarcinoma
Wenjuan Zhu†, Wenzhe Gao†, Yanyao Deng, Xiao Yu*, Hongwei Zhu*
Autophagy Regulatory Genes MET and RIPK2 Play a Prognostic Role in Pancreatic Ductal Adenocarcinoma: A Bioinformatic Analysis Based on GEO and TCGA
Xingyu Li, Zhiqiang Li, Hongwei Zhu, Xiao Yu*
Multiomics integrative analysis for gene signatures and prognostic values of m6A regulators in pancreatic adenocarcinoma: a retrospective study in The Cancer Genome Atlas project
Wenzhe Gao, Liuyang Cheng, Shuhan He, Wei Li, Chengyu Zhou, Bixia Zhou, Jiamiao Liu, Jiahao Xu, Xiao Yu*, Hongwei Zhu*
The risk of rheumatoid arthritis among patients with inflammatory bowel disease: a systematic review and meta-analysis
Yi Chen, Lang Chen, Changsheng Xing, Guangtong Deng, Furong Zeng, Tingting Xie, Lei Gu, Huixiang Yang*
CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis
Jiale Wang, Xia Li, Yunfei Liu, Cheng Peng, Hongwei Zhu, Guangping Tu, Xiao Yu*, Zhiqiang Li*
CircHIPK3 Promotes Gemcitabine (GEM) Resistance in Pancreatic Cancer Cells by Sponging miR-330-5p and Targets RASSF1
Yunfei Liu, Li Xia, Luo Dong, Jiale Wang, Qiangsheng Xiao, Xiao Yu*, Hongwei Zhu*
The MicroHand S robotic-assisted versus Da Vinci robotic-assisted radical resection for patients with sigmoid colon cancer: a single-center retrospective study
Dong Luo, Yunfei Liu, Hongwei Zhu, Xia Li, Wenzhe Gao, Xinyu Li, Shaihong Zhu, Xiao Yu*
The role of interleukin-18 in pancreatitis and pancreatic cancer
Zhiqiang Li, Xiao Yu, Jens Werner, Alexandr V Bazhin*, Jan G D'Haese*
Long Noncoding RNA HCP5 Regulates Pancreatic Cancer Gemcitabine (GEM) Resistance By Sponging Hsa-miR-214-3p To Target HDGF
Yunfei Liu, Jiale Wang, Luo Dong, Li Xia, Hongwei Zhu, Zhiqiang Li*, Xiao Yu*
Autotaxin upregulated by STAT3 activation contributes to invasion in pancreatic neuroendocrine neoplasms
Linfei Yang, Xiao Yu, Yongchao Yang*
Exendin-4 impairs the autophagic flux to induce apoptosis in pancreatic acinar AR42J cells by down-regulating LAMP-2
Zhiqiang Li, Shaihong Zhu, Lihua Huang, Mingming Shang, Can Yu, Hongwei Zhu, Duo Han, Hui Huang, Xiao Yu*, Xia Li*
RIP-1/c-FLIPL Induce Hepatic Cancer Cell Apoptosis Through Regulating Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
Jichun Sun, Xiao Yu, Changfa Wang, Can Yu, Zhiqiang Li, Wanpin Nie, Xundi Xu, Xiongying Miao, Xiaoxin Jin*
Exenatide Induces Impairment of Autophagy Flux to Damage Rat Pancreas
Zhiqiang Li, Lihua Huang, Xiao Yu*, Can Yu, Hongwei Zhu, Xia Li, Duo Han, Hui Huang
Expression pattern of HMGB1 and its association with autophagy in acute necrotizing pancreatitis
Can Yu, Xiao Yu*, Hongwei Zhu, Xia Li, Lihua Huang, Zhiqiang Li, Duo Han, Hui Huang
Regulation of autophagy by systemic admission of microRNA-141 to target HMGB1 in l-arginine-induced acute pancreatitis in vivo
Hongwei Zhu, Lihua Huang, Shaihong Zhu, Xia Li, Zhiqiang Li, Can Yu, Xiao Yu*
The fusion of autophagosome with lysosome is impaired in L-arginine-induced acute pancreatitis
Hongwei Zhu, Xiao Yu, Shaihong Zhu, Xia Li, Ben Lu, Zhiqiang Li, Can Yu
Spatial and temporal differences of HMGB1 expression in the pancreas of rats with acute pancreatitis
Can Yu, Lihua Huang, Xia Li, Hongwei Zhu, Zhiqiang Li, Xiao Yu
GLP-1R agonist may activate pancreatic stellate cells to induce rat pancreatic tissue lesion
Yongchao Yang, Xiao Yu*, Lihua Huang, Can Yu
Exenatide-induced chronic damage of pancreatic tissue in rats
Xiao Yu*, Huayong Tang, Lihua Huang, Yongchao Yang, Buning Tian, Can Yu