Research Directions
Pancreatitis
Pathogenesis, progression, and associated complications of acute pancreatitis.
Pancreatic Cancer
Molecular mechanisms and translational research in pancreatic cancer.
Clinical Bioinformatics
Mining clinical datasets to uncover mechanisms and predictors.
Funded Projects
PKC-ε/MLKL/BRD4 Axis Exacerbates Acute Pancreatitis-Associated Lung Injury by Inducing Alveolar Macrophage Pyroptosis via Exosomal S100A9
2025-01-01 to 2028-12-31, CNY 490,000, Host by Xiao Yu.
General Program of the National Natural Science Foundation of China (82472226).
IGF2BP3 Stabilizes S100A16 Expression to Induce Glutamine Metabolism Dysregulation and Promote Malignant Proliferation in Pancreatic Cancer
2023-01-01 to 2025-12-31, CNY 300,000, Host by Wenzhe Gao.
Young Scientists Fund of the National Natural Science Foundation of China (82203494).
IL-18 and IL-3 Synergistically Regulate the STAT3/IL-4 Pathway in Pancreatic Stellate Cells in Chronic Pancreatitis
2022-01-01 to 2024-12-31, CNY 300,000, Host by Zhiqiang Li.
Young Scientists Fund of the National Natural Science Foundation of China (82203494).
m6A Reader IGF2BP2 Mediates Autophagy via Stabilizing ULK1/Beclin-1 Signaling Axis to Promote Acute Pancreatitis Pathogenesis
2021-01-01 to 2023-12-31, CNY 240,000, Host by Hongwei Zhu.
Young Scientists Fund of the National Natural Science Foundation of China (82000614).
LncRNA MEG3/miR-21 Mediates Impaired Autophagic Flux through LAMP-2 to Trigger Necroptosis and Exacerbate Acute Pancreatitis
2019-01-01 to 2022-12-31, CNY 570,000, Host by Xiao Yu.
General Program of the National Natural Science Foundation of China (81873589).
mTORC2/CTGF Signaling Mediates Incretin Mimetics-Induced Chronic Pancreatic Fibrosis Injury
2016-01-01 to 2019-12-31, CNY 570,000, Host by Xiao Yu.
General Program of the National Natural Science Foundation of China (81570585).
HMGB1 Induces Autophagic Signaling to Exacerbate Acute Pancreatitis Injury
2013-01-01 — 2013-12-31, CNY 130,000, Host by Xiao Yu.
General Program of the National Natural Science Foundation of China (81270545).
"Shenghua Scholar" Program of Central South University
2025-01-01 — Present, CNY 500,000, Host by Hongwei Zhu.
"Shenghua Scholar" Program of Central South University.
2024 National Clinical Key Specialty Cultivation Project of the Department of Hepatopancreatobiliary Surgery
2025-01-01 — Present, Host by Xiao Yu.
National Clinical Key Specialty Cultivation Project of the Health Commission of Hunan Province.
SLC7A11-High Pancreatic Cancer Subtype Exhibits Sensitivity to Erlotinib
2025-01-01 — 2027-12-31, Host by Xiao Yu.
Key Health Research Project of the Health Commission of Hunan Province (20255741).
Histone Acetylation-Mediated m6A Reader IGF2BP2 Regulates S100A16 to Promote EMT in Pancreatic Cancer
2024-01-01 — 2026-12-31, Host by Hongwei Zhu.
General Program of the Natural Science Foundation of Hunan Province (S2024JJMSXM2874).
The Wisdom Accumulation and Talent Cultivation Project of The Third Xiangya Hospital of Central South University
2023-01-01 — 2027-12-31, CNY 500,000, Host by Hongwei Zhu.
The Wisdom Accumulation and Talent Cultivation Project of The Third Xiangya Hospital of Central South University (202204015341).
Histone Methylation-Mediated m6A Reader IGF2BP3 Regulates Glycolysis in Pancreatic Cancer
2022-01-01 — 2024-12-31, Host by Wenzhe Gao.
Youth Program of the Natural Science Foundation of Hunan Province (2022JJ40741).
m6A Reader IGF2BP3 Stabilizes NEK2 to Mediate the Cell Cycle and Contribute to Pancreatic Cancer Pathogenesis
2022-01-01 — 2024-12-31, CNY 40,000, Host by Hongwei Zhu.
The Health Commission of Hunan Province Project (202204015341).
MLKL-HMGB1 Pathway Activates NLRP3 Inflammasome to Exacerbate Acute Pancreatitis-Associated Lung Injury
2021-01-01 — 2023-12-31, Host by Xiao Yu.
General Program of the Natural Science Foundation of Hunan Province (S2021JJMSXM2536).
Development of a Science Popularization Project for Hyperlipidemic Pancreatitis and Obesity Prevention: Combining Multi-Platform Exercise Logging, Nutritional Guidance, and Warning Education
2021-06-01 — 2022-5-31, Host by Xiao Yu.
Inclusive Policy and Innovation Environment Construction Program of Hunan Province: Science Popularization Special Topic (S2021JJMSXM2536).
The Circ_0002345/miR-143-3p/VMP1 Axis Promotes Autophagy Hyperactivation to Aggravate Acute Pancreatitis
2020-01-01 — 2022-12-31, Host by Hongwei Zhu.
Youth Program of the Natural Science Foundation of Hunan Province (2020JJ5876).
Restoring Impaired Autophagic Flux Inhibits Necroptosis to Alleviate Severe Acute Pancreatitis
2018-01-01 — 2020-12-31, Host by Xiao Yu.
Science and Technology Innovation Program of Hunan Province (2017SK50129).